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US firm Artivion sets $335m deal to buy Israel’s Endospan

Artivion, a US-listed medical device company, said it will buy Israeli stent maker Endospan outright for about US$135 million in cash after the FDA approved Endospan’s Nexus system for treating aortic arch disease on April 2.

The agreement sets a base value of US$175 million, but Artivion said the net cash payment will be lower after deducting Endospan’s debt and earlier loans from Artivion.

The deal could rise by up to US$200 million if Nexus meets US commercial milestones about two years after closing, and it still depends on due diligence, regulatory approvals, and other standard conditions.

🔗 Source: Calcalist

🧠 Food for thought

Implications, context, and why it matters.

The acquisition followed a long-running plan

  • Artivion did not move because of a sudden regulatory update. The purchase closed a strategy that had been in place for years 1.
  • In 2019, Artivion secured an option to buy Endospan. The agreement let it act within 90 days of notice that the Nexus system had won FDA approval 1.
  • To help Endospan reach that milestone, Artivion backed commercialization efforts. In July 2024, it offered up to US$25 million in debt financing 2.
  • Before approval arrived, Artivion also lined up a US$150 million delayed-draw term loan, a loan a company can tap later, to fund a possible purchase 1.

Artivion adds a technology with room to grow

  • The buyout gives Artivion full ownership of the Nexus Aortic Arch System, a minimally invasive device cleared in the U.S. for aortic arch disease, including chronic aortic dissections 1.
  • That product targets an estimated US$600 million in annual global market opportunity 2.
  • Investors welcomed the move. Artivion shares rose 15.31% in the seven days after the FDA approval announcement 3.
  • The deal fits a wider medical device pattern. Larger companies often fund startups through regulatory hurdles, then complete a full acquisition in the cardiovascular device market 4.

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